OCERAL

OCERAL contains a synergistic blend of active pharmaceutical ingredients engineered to provide comprehensive dermatological treatment: * **Betamethasone Dipropionate (0.05%):** A highly potent topical corticosteroid, this ingredient exerts its therapeutic effects by binding to glucocorticoid receptors within the cytoplasm of target cells. This complex then translocates to the nucleus, modulating gene expression to inhibit the synthesis of inflammatory mediators such as prostaglandins and leukotrienes. Its potent anti-inflammatory, immunosuppressive, and vasoconstrictive properties effectively reduce erythema, edema, and pruritus associated with various dermatoses. * **Clotrimazole (1%):** A broad-spectrum imidazole antifungal, Clotrimazole acts by inhibiting the biosynthesis of ergosterol, a crucial component of fungal cell membranes. This disruption leads to structural and functional impairment of the fungal cell membrane, resulting in increased permeability, leakage of essential intracellular components, and ultimately, fungal cell death. It is effective against a wide range of dermatophytes, yeasts, and other pathogenic fungi. * **Salicylic Acid (3%):** A well-established keratolytic agent, Salicylic Acid works by dissolving the intercellular cement that binds corneocytes in the stratum corneum. This promotes desquamation and facilitates the shedding of hyperkeratotic scales, softening the skin and enhancing the penetration of other active ingredients. It also possesses mild antiseptic and anti-inflammatory properties.

For optimal therapeutic outcomes, adhere strictly to the following application instructions: 1. **Skin Preparation:** Before each application, gently cleanse the affected skin area with a mild, non-irritating cleanser and pat dry thoroughly. Ensure the skin is completely dry to facilitate proper absorption of the product. 2. **Application Frequency:** Apply OCERAL thinly to the affected skin area twice daily, typically in the morning and evening, or as directed by your healthcare professional. Do not exceed the recommended frequency. 3. **Amount to Apply:** Squeeze a small amount of cream onto your fingertip. Apply just enough to form a thin, even layer that covers the entire affected area and a small margin of surrounding healthy skin. Gently massage until the cream is absorbed. Avoid excessive application, as this does not enhance efficacy and may increase the risk of side effects, especially with prolonged corticosteroid use. 4. **Duration of Treatment:** The typical duration of treatment ranges from 2 to 4 weeks, depending on the severity and nature of the condition. Do not use OCERAL for longer than prescribed without consulting your doctor, particularly in sensitive areas or on large body surfaces, due to the corticosteroid component. 5. **When to Expect Results:** Patients often experience noticeable relief from symptoms such as itching and redness within the first few days of treatment. Significant improvement in skin appearance and texture can usually be observed within 1 to 2 weeks. 6. **Tips for Maximum Effectiveness:** Maintain consistent application as prescribed. Avoid contact with eyes and mucous membranes. Wash hands thoroughly after application unless the hands are the area being treated. For fungal infections, continue treatment for a few days after symptoms resolve to prevent recurrence. Avoid occlusive dressings unless specifically advised by your physician.

OCERAL is indicated for the topical treatment of various dermatological conditions characterized by inflammation, pruritus, hyperkeratosis, and suspected or confirmed fungal infection. * **Primary Indications:** This includes conditions such as tinea corporis, tinea cruris, tinea pedis (athlete's foot), and tinea manuum, especially when accompanied by significant inflammatory symptoms like erythema and edema. It is also effective in managing inflammatory dermatoses complicated by secondary fungal infections, such as certain forms of eczema, intertrigo, and seborrheic dermatitis, particularly those presenting with scaling and itching. Its keratolytic action makes it beneficial for hyperkeratotic lesions like localized psoriasis. * **Secondary Benefits:** Beyond treating the primary condition, OCERAL rapidly alleviates associated symptoms including intense pruritus, erythema, scaling, and discomfort, thereby improving patient quality of life and promoting faster skin regeneration. * **Skin Types Suitable for Use:** OCERAL is generally suitable for use on most skin types, though caution should be exercised on very sensitive facial skin or thin skin areas due to the potent corticosteroid component. It is particularly beneficial for skin areas prone to moisture and friction where fungal infections commonly thrive.

Prior to using OCERAL, carefully review the following important safety information: * **Contraindications:** OCERAL is contraindicated in individuals with known hypersensitivity to betamethasone dipropionate, clotrimazole, salicylic acid, or any excipients. It should not be used in cases of viral skin infections (e.g., herpes simplex, varicella), tuberculosis of the skin, acne vulgaris, rosacea, perioral dermatitis, or extensive non-diagnosed fungal infections. Avoid application to open wounds or broken skin. * **Potential Side Effects:** While generally well-tolerated, some individuals may experience local side effects such as mild burning, itching, irritation, dryness, or folliculitis at the application site. Prolonged or extensive use, especially under occlusion, may lead to skin atrophy, striae, telangiectasias, hypertrichosis, hypopigmentation, and rarely, systemic absorption leading to Cushing's syndrome or adrenal suppression. If severe irritation or any unusual reaction occurs, discontinue use and consult a physician. * **Drug Interactions:** No significant systemic drug interactions are anticipated with the topical application of OCERAL. However, inform your doctor or pharmacist about all other medications you are currently using, including over-the-counter products. * **Special Populations:** * **Pregnancy and Lactation:** OCERAL should be used during pregnancy or breastfeeding only if the potential benefit justifies the potential risk to the fetus or infant, and only under strict medical supervision. Avoid application to large areas or for prolonged periods. * **Children:** Children are more susceptible to systemic absorption of corticosteroids due to a larger skin surface area to body weight ratio. Use in children should be limited to the smallest effective amount for the shortest possible duration, and under close medical guidance. * **When to Consult a Doctor:** Seek immediate medical advice if your condition worsens, if there is no improvement after 7-10 days of treatment, if you develop severe local irritation, or if you experience any signs of systemic adverse effects.